To conduct a comparative analysis of daily parameters of aortic pressure and stiffness in patients with metabolic syndrome (MS) and arterial hypertension of 1–2 degrees (AH) with signs of left ventricular hypertrophy (LVH) and without.Design and Method:
122 subjects with three or more criteria for MS. The inclusion criterion was the presence of arterial hypertension of 1–2 degrees. All patients underwent the echocardiography (MyLab 90, Esaote, Italy), based on the results of which the patients were divided into 2 groups. The group1 consisted of 53 subjects with signs of LVH (LVMI values for men ≥ 125 g/m2 for women ≥ 110 g/m2). Group 2 included 69 patients with MS and normal values of LVMMI. Patients were matched for age, height, systolic and diastolic BP. Structural and functional properties of large arteries were analyzed according to ambulatory BP monitoring BpLab (“Peter Telegin”, Russia) to estimate the average value of the central (aortic) pressure and vascular stiffness (SBPao, DBPao, MBPao, PPao, Aixao, RWTT).Results:
At comparable office BP values compared groups differed significantly on the values of SBPao (in group 1 -133.7 ± 12.8 mmHg, in group 2–127.8 ± 8.7 mmHg, p < 0.01), MBPao (in patients with LVH–111.0 ± 11.5 mmHg, in patients with normal values LVMMI–105.4 ± 8.5 mmHg, p < 0.01) and PPao (group 1–44.7 ± 9.7 mmHg, in group 2–40.5 ± 5.5 mmHg, p = 0.01) with comparable values of DBPao (89.4 ± 9.3 and 87.5 ± 8.3 mmHg, respectively; p = 0.24). No significant differences in the average daily level of Aixao have been identified: patients with LVH–24.2 ± 12.5%, in the comparison group–21.4 ± 13.2% (NS). Indicator RWTT in group 1 was 130.9 ± 9.2 ms, in group 2–136.1 ± 9.6 ms (p < 0.01).Conclusions:
In patients with metabolic syndrome the signs of left ventricle hypertrophy were accompanied by a deterioration of most daily parameters of central pressure and stiffness.