PS 11-48 IMPACT OF TAURINE SUPPLEMENTATION ON ABDOMINAL OBESITY HIGH-NORMAL BLOOD PRESSURE

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Abstract

Objective:

Sulfur-containing amino acids (SAA) have recently been associated with cardiovascular disease, and metabolism of SAA was closely related to taurine. Therefore, the current study was to investigate the effect of taurine on blood pressure and metabolism indexes in people with abdominal obesity high-normal blood pressure.

Design and Method:

Randomized double-blind, double simulation method was conducted. The inclusion criteria was BMI ≥ 24.0 kg/m2, abdominal obesity (abdomen circumference male ≥90 cm, female ≥85 cm), and SBP 120∼139 mmHg, DBP 80∼89 mmHg, age 25∼75 years, except patients with hypertension, diabetes and cardiovascular diseases. Objects were randomly divided into taurine supplement (0.8 g/day) group and placebo (same appearance, taste with taurine) group by the computer system, then were followed up of 3 months to observe BMI, abdomen circumference, blood pressure and blood metabolism indexes.

Results:

A total of 200 cases were randomly divided into two groups in each group 100 cases. There was no significant difference in baseline BMI, abdomen circumference (AC), blood pressure between two groups. Compare the change of above indicators after 3 months follow-up, we found AC reduced significantly in taurine supplement group compare with placebo group (−4.88 ± 5.62 vs −2.33 ± 6.01, P = 0.036), and LDL-C decreased relatively (−0.33 ± 0.64 vs −0.07 ± 0.58, P = 0.01). There was no difference between two groups in change of BMI (0.04 ± 0.88 vs −0.34 ± 1.51, P = 0.14), SBP (2.99 ± 13.96 vs 1.63 ± 11.90, P = 0.53), DBP (−1.70 ± 8.96 vs −0.57 ± 7.72, P = 0.42), fasting plasma glucose (0.12 ± 1.28 vs 0.14 ± 1.61, P = 0.30), triglycerides (0.31 ± 1.48 vs 0.06 ± 1.58, P = 0.32), total cholesterol (−0.24 ± 0.63 vs −0.17 ± 0.75, P = 0.53), HDL-C (0.04 ± 0.37 vs 0.04 ± 0.24, P = 0.93).

Conclusions:

Taurine supplement might be beneficial to control abdominal obesity and blood lipid especially low density lipoprotein cholesterol.

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