PS 11-60 SERUM VITAMIN D IS NEGATIVELY ASSOCIATED WITH METABOLIC SYNDROME BUT POSITIVELY ASSOCIATED WITH CORONARY ARTERY CALCIFICATION.

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Abstract

Objective:

Vitamin D may play a role in the etiology of the metabolic syndrome (MetS). However, the association between Vitamin D and coronary artery calcification is still unclear. The objective of the study was to examine the association of vitamin D with MetS and its traditional and nontraditional components and coronary artery calcification(CAC) in a large Korean male subjects.

Design and Method:

In this cross-sectional study, we examined 98,412 participants from Kangbuk Samsung health study. To assess vitamin D status, serum 25-hydroxyvitamin D3 (OH)D3 was measured. All computed tomography scans were obtained with a Light speed VCT XTe-64 slice MDCT scanner. To evaluate the association of outcome variables and Vitamin D quartiles we used a binomial logistic regression model to estimate odds ratios (ORs) with 95% confidence intervals (CI) for CAC.

Results:

The vitamin D level in Korean male subjects is lower than Caucasian's Approximately 15% of the study participants were classified as having MetS. Higher vitamin D(4th quartile) was significantly associated with a reduced presence of MetS (18% reduction after adjustments of age, center, year, smoking, alcohol, education, physical activity, and season). But higher vitamin D level was associated with increased CAC. Multivariate linear regression analyses indicated significant adjusted associations of Vitamin D with CAC.

Conclusions:

Serum vitamin D level was negatively associated with MetS but positively associated with CAC, an important maker of atherosclerosis. These results suggest that the effect of vitamin D on cardiovascular disease is still unclear.

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