PS 11-61 STATUS OF INFLAMMATION AND ENDOTHELIAL ACTIVATION AMONG NATIVE GROUPS WITH METABOLIC SYNDROME IN MALAYSIA

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Abstract

Objective:

To: (1) determine the prevalence of metabolic syndrome (MS) in three native groups (Malay, Bidayuh and Orang Asli) in Malaysian cohort, (2) compare concentrations of biomarkers of inflammation and endothelial activation between MS, obesity without MS (OBXMS) and non-MS subjects across the three native groups.

Design and Method:

A total of 1,517 subjects were recruited comprising of 1,227 Malays, 75 Bidayuh and 215 Orang Asli in this cross sectional study. Two hundred eighty three (283) subjects were MS, 460 subjects were OBXMS and 774 subjects were non-MS by IDF criteria. Serum samples were collected for analysis of biomarkers of inflammation [high-sensitivity C-reactive protein (hsCRP)] and endothelial activation [soluble Intercellular Adhesion Molecule-1 (sICAM-1)].

Results:

Amongst the Malays, 247(20.1%), 423(34.5%) and 557(45.4%) were MS, OBXMS and non-MS respectively. The Bidayuh comprised of 19(25.3%) MS, 14(18.7%) OBXMS and 42(56%) non-MS. Seventeen (7.9%), 23(10.7%) and 175(81.4%) were MS, OBXMS and non-MS respectively among the Orang Asli group. Overall, MS and OBXMS subjects had higher hsCRP than non-MS [hscrp ± SD (mg/L) = 2.90 ± 2.21, 2.95 ± 2.53 and 1.59 ± 1.93, MS, OBXMS and non-MS respectively, p < 0.001]. Amongst the Malays, MS and OBXMS subjects had higher hsCRP than non-MS subjects [(hscrp ± SD (mg/L) = 2.99 ± 2.27, 2.87 ± 2.50 and 1.54 ± 1.92, MS, OBXMS and non-MS respectively, p < 0.001]. The Orang Asli OBXMS groups had higher hsCRP than MS and non-MS subjects [hscrp ± SD (mg/L) = 4.48 ± 2.86, 2.41 ± 1.83 and 1.81 ± 1.96, OBXMS, MS and non-MS respectively, p < 0.001]. There were no significant differences between MS, COBXMS and non-MS among the Bidayuh for both biomarkers and sICAM-1 in all native groups (p > 0.05).

Conclusions:

MS is associated with enhanced inflammation but not endothelial activation in the three native groups. In addition, higher inflammatory status found in simple obesity and not in MS in Orang Asli suggest that obesity is the predominant component influencing inflammation in the subgroup compared to other MS criteria.

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