PS 11-77 COMPARISON OF CALCIUM CHANNEL BLOCKERS VERSUS CALCIUM CHANNEL BLOCKERS WITH ANGIOTENSIN RECEPTOR BLOCKERS ON THE DEVELOPMENT OF NEW-ONSET DIABETES MELLITUS IN HYPERTENSIVE PATIENTS

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Abstract

Objective:

Recently several studies reported that anti-hypertensive drugs were associated with development of new-onset diabetes mellitus (NODM). However, data on the relationship between detailed prescription types and long-term incidence of NODM are still limited, particularly in Asian patients (pts).

Design and Method:

A total of 3,208 consecutive hypertension pts prescribed with calcium channel blockers (CCB) were enrolled with the exclusion of diabetic pts. Pts were divided into two groups according to the additional prescription of angiotensin receptor blockers (ARB); 1) the CCB group (n=1,987) and 2) CCB+ARB group (n=1,221). NODM was defined as having a fasting blood glucose ≥126mg/dL or HbA1c ≥6.5%. To adjust for potential confounders, a propensity score matching (PSM) analysis was performed using the logistic regression model. Primary end-point was NODM and in addition, individual and composite major adverse cerebro-cardiac events (MACCE) were compared between the two groups up to 5 years.

Results:

After PSM analysis, two propensity-matched groups (758 pairs, n=1,516, C-statistic=0.751) were generated and the baseline characteristics were balanced. Up to 5 years, there was no significant difference in the incidence of NODM, total death, myocardial infarction, stroke, percutaneous coronary intervention (PCI) and composite MACCE between the two groups except higher trend of stroke in the CCB+ARB group (Table).

Conclusions:

In our study, there were no differences in the incidence of NODM and major clinical outcomes between the CCB group and CCB+ARB group.

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