PS 14-40 INVESTIGATION OF THE EFFICACY AND SAFETY OF BISOPROLOL TRANSDERMAL PATCH IN JAPANESE PATIENTS WITH TYPE 2 DIABETES MELLITUS AND HEART DISEASE

    loading  Checking for direct PDF access through Ovid

Abstract

Objective:

The efficacy and safety of the world's first bisoprolol transdermal patch (BTP) on the blood pressure and the glycemic control of patients with type 2 diabetes mellitus (T2DM) and hypertension is unknown. We investigated the effect of beta1-selective beta-blocker on office blood pressure and home morning blood pressure, following the effect of the glycemic and metabolic control in patients with T2DM and cardiovascular disease.

Design and Method:

Twenty-five patients (mean age 68 ± 9 years, 10 males) with heart disease and stable T2DM (glycated hemoglobin level [HbA1c] of 8% or less, no urine sugar and no urine protein) without insulin therapy were administered once-daily BTP 4 mg at 9 p.m. and were followed up. The mean follow-up period was 85 days.

Results:

In regards to office blood pressure, BTP significantly reduced the diastolic blood pressure (DBP) from 82 ± 8 mmHg to 77 ± 8 mmHg (P < 0.05) and pulse-rate (PT) from 68 ± 9 beats per minute to 56 ± 10 beats per minute (P < 0.01), respectively, although there was no significant change in systolic blood pressure (SBP): 145 ± 14 mmHg at baseline, 142 ± 11 mmHg at 85 days. For home morning blood pressure, SBP, DBP and PT achieved the target home blood pressure goal (SBP: 125 ± 11 mmHg, DBP: 72 ± 8 mmHg, PT: 56 ± 10 beats per minute) at the first week of the administration and were maintained (SBP: 124 ± 11 mmHg, DBP: 70 ± 10 mmHg, PT: 53 ± 6 beats per minute) at the fourth week. HbA1c (6.9 ± 0.6%) and body weight (BW) (66.0 ± 7.7 kg) at baseline were not altered during BTP therapy (HbA1c: 6.9 ± 0.6%, BW: 66.1 ± 8.0 kg at 85 days). Moreover, there was no variation in urine sugar and urine protein, and there was no occurrence of hypoglycemia or cardiac decompensation for the duration of this study.

Conclusions:

The administration of BTP at bedtime controlled the office blood pressure and the home morning blood pressure effectively, without the adverse effect of T2DM control.

Related Topics

    loading  Loading Related Articles