To compare therapeutic response of angiotensin converting enzyme blockers (ACE) inhibitor in reducing blood pressure between Melanesian and Non Melanesian hypertensive patients.Design and Method:
This study is a prospective cohort study conducted in the city of Jayapura September to November 2015. We found 85 subjects aged 30 to 55 years old with hypertension never be treated before. Subjects are divided into two groups, namely the Melanesian race (n = 34) and non Melanesian race (n = 51). Both groups were given an initial dose of 5 mg of lisinopril. Blood pressure checks performed at baseline and repeated every 7 days for 4 weeks in a row.Results:
There are differences in the response of blood pressure in hypertensive patient of Melanesian race and Non Melanesia race. Reduction of systolic blood pressure of 24.5 ± 9.4 mmHg in subject Melanesian race and on the subject of Non Melanesian 34.5 ± 13.5 mmHg (p < 0.001). Reduction of diastolic blood pressure of subjects Melanesians of 13.3 ± 5.5 mmHg, and on the subject of Non Melanesia 22.6 ± 9.3 mmHg (p < 0.001). Reduction of mean arterial pressure in subject Melanesian race at 17.1 ± 5.6 mmHg and Non Melanesian race at 26.21 ± 8.8 mmHg (p < 0.001). Mean Plasma Renin Activity (PRA) on the subject of the Melanesian race at 1.48 [1.86] ng/ml/h and on the subject of non Melanesian race PRA average level of 1.1 [1.47] ng/ml/hr (p = 0.564).Conclusions:
There are differences in blood pressure reduction (systolic, diastolic pressure and mean arterial pressure) with administer of ACE inhibitor in Melanesian and Non Melanesia group of race. There is no significant relation with average PRA levels in both group of race. Another factors affects responses of reduction blood pressure with administer of ACE inhibitor may be considered.