PS 14-60 THE IMPACT OF COMPOUND DANSHEN DRIPPING PILLS ON ARTERIAL STIFFNESS AND ATHEROSCLEROSIS IN PATIENTS WITH HYPERTENSION

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Abstract

Objective:

Hypertension is a common chronic disease. Arterial stiffness and arteriosclerosis are the main pathological features of hypertension. We observed the effect of Compound Danshen Dripping Pills(CDDP) combined with statins on arterial stiffness and atherosclerosis in patients with hypertension.

Design and Method:

Between 2012 and 2014,160 patients with hypertension were selected and randomly divided into the CDDP group (n = 84, conventional anti-hypertensive + CDDP + statins) and the Control group (n = 76, conventional anti-hypertensive + statins). After 11 months, the related data of all patients were collected before and after treatment.

Results:

1. The brachial-ankle pulse wave(baPWV)of both groups after treatment was significantly lower than that before treatment(P < 0.05), the baPWV in the CDDP group significantly decreasd (P < 0.05). 2. The intima-media thickness(IMT)of carotid artery of both groups after treatment was significantly lower than that before treatment(P < 0.05), and the IMT of carotid artery in the CDDP group significantly decreased (P < 0.05).3. Triglyceride (TG), total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) levels of two groups after treatment significantly decreased (P < 0.05). The LDL-C level in the CDDP group was significantly lower than that in the Control group (P < 0.05). 4. The level of serum MDA content of two groups after treatment markedly increased and the activity of SOD of two groups after treatment significantly decreased (P < 0.01). Compared with the Control group, the level of serum MDA content of the CDDP group after treatment significantly increased, whereas the activity of SOD of the CDDP group after treatment significantly decreased(P < 0.01).

Conclusions:

CDDP combined with statins can further improve arterial stiffness and prevent the progression of atherosclerosis in patients with hypertension, the mechanism may be related to inhibition of oxidative stress and regulation of lipid metabolism.

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