PS 17-15 THE RELATIONSHIP BETWEEN OBSTRUCTIVE SLEEP APNEA AND IMMUNOSENESCENCE IN HYPERTENSIVE PATIENTS

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Abstract

Objective:

Hypertension was considered to be associated with chronic inflammation by adaptive immune response of T cells in previous animal study. Obstructive sleep apnea (OSA) was associated with chronic inflammation by repetitive oxidative stress. Immunosenescence (IS) parameters, CD28null and CD57+ fraction in CD8 T cells were increased in hypertensive patients in previous human research. This study was to demonstrate the association of chronic inflammation and IS parameters with OSA in hypertensive patients.

Design and method:

Multicenter longitudinal observational study from April 2013 to October 2015. Hypertensive patients (SBP > 140 mmHg or DBP > 90 mmHg) were devided into OSA low risk and OSA high risk according to Berlin sleep apnea questionnaire. CD28 null and CD58 (+) fraction of CD8 T-cells were sampled at baseline in both groups.

Results:

A total of 131 consecutive patients were enrolled in this study. Among them, 88 patients (67.2%) were OSA high risk, and 43 patients (32.8%) were OSA low risk. OSA high risk group had a higher diastolic blood pressure (DBP) (90.1±10.2 vs 84.2 ± 10.4, p = 0.002), lower high density lipoprotein (HDL) (48.2 ± 11.9 vs 53.9 ± 10.7, p = 0.016), higher uric acid (5.7 ± 1.3 vs 4.8 ± 1.6, p  =  0.005) compared with OSA low risk group.

Results:

CD28 null fraction of CD8 T cells in OSA high risk group was 35.1 ± 18.3% vs 43.9 ± 19.9% in low risk group with a p-value 0.014. CD58+ fraction of CD8 T-cells in OSA high risk group was 37.0 ± 16.9% vs 44.7 ± 20.0% in OSA low risk group with a p-value 0.023.

Conclusions:

Hypertensive patients with OSA had a worse clinical characteristics than those without OSA. However IS parameters, CD28 null and CD58 (+) fraction of CD8 T-cell were paradoxically higher in patients without OSA. Further research will be needed to determine the impact of OSA on chronic inflammation and IS.

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