Hypertension was considered to be associated with chronic inflammation by adaptive immune response of T cells in previous animal study. Obstructive sleep apnea (OSA) was associated with chronic inflammation by repetitive oxidative stress. Immunosenescence (IS) parameters, CD28null and CD57+ fraction in CD8 T cells were increased in hypertensive patients in previous human research. This study was to demonstrate the association of chronic inflammation and IS parameters with OSA in hypertensive patients.Design and method:
Multicenter longitudinal observational study from April 2013 to October 2015. Hypertensive patients (SBP > 140 mmHg or DBP > 90 mmHg) were devided into OSA low risk and OSA high risk according to Berlin sleep apnea questionnaire. CD28 null and CD58 (+) fraction of CD8 T-cells were sampled at baseline in both groups.Results:
A total of 131 consecutive patients were enrolled in this study. Among them, 88 patients (67.2%) were OSA high risk, and 43 patients (32.8%) were OSA low risk. OSA high risk group had a higher diastolic blood pressure (DBP) (90.1±10.2 vs 84.2 ± 10.4, p = 0.002), lower high density lipoprotein (HDL) (48.2 ± 11.9 vs 53.9 ± 10.7, p = 0.016), higher uric acid (5.7 ± 1.3 vs 4.8 ± 1.6, p = 0.005) compared with OSA low risk group.Results:
CD28 null fraction of CD8 T cells in OSA high risk group was 35.1 ± 18.3% vs 43.9 ± 19.9% in low risk group with a p-value 0.014. CD58+ fraction of CD8 T-cells in OSA high risk group was 37.0 ± 16.9% vs 44.7 ± 20.0% in OSA low risk group with a p-value 0.023.Conclusions:
Hypertensive patients with OSA had a worse clinical characteristics than those without OSA. However IS parameters, CD28 null and CD58 (+) fraction of CD8 T-cell were paradoxically higher in patients without OSA. Further research will be needed to determine the impact of OSA on chronic inflammation and IS.