PS 17-34 RELATIONSHIP BETWEEN EXISTENCE OF DIABETES MELLITUS AND CAROTID ARTERY ATHEROSCLEROTIC LESION IN PATIENTS WITH ARTERIAL HYPERTENSION

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Abstract

Objective:

Arterial hypertension (AH) as well as diabetes mellitus (DM) are considered as important cardiovascular risk-factors, which are associated with high rate of mortality and morbidity. Independent influence of AH level on severity of carotid artery (CA) disease was not revealed in our clinical study. Therefore, we hypothesized that DM in connection with AH leads to increased probability of severe atherosclerotic lesion of CAs.

Design and method:

124 patients (mean age ± SD, 67.35 ± 9.2 years), 64 men and 60 women were included in the study. All of them had one or both CA disease, DM and AH. Blood pressure was measured in an office according to the standard protocol. For diagnostics of the CA disease was used high resolution ultrasound. CA disease was assessed as a number of atherosclerotic plaques and existence of lumen stenosis in different parts of it.

Results:

58% of patients (n = 72) had DM and 1st stage AH. Plaque scores in left and right CAs were not different and was 2.7 in both sides. Hemodynamically non-significant stenosis was revealed in 87.5% right and 86% left CAs (P = NS). Plaque score, as well as level of hemodynamically significant stenosis also was not significantly different in patients with DM and 2nd and 3rd stage of AH; namely, 2.5/2.6 and 14%/16% vs 2.5/2.5 and 14%/14% in right and left CAs consequently.

Conclusions:

According to the study data we can conclude that DM and level of AH separately, as well as cumulatively does not affect CA disease existence and severity, assessed by CA plaque score and stenosis’ extent.

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