PS 17-36 THE CHARACTERISTICS OF ARTERIAL STIFFNESS AND CARDIAC REMODELING IN MIDDLE-AGED FEMALE HYPERTENSIVE PATIENTS

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Abstract

Objective:

We hypothesized that cardiac remodeling would be associated with correlation index of arteriosclerosis. And there are differences between males and females. The purpose of this study is to illustrate the characteristics of the arterial stiffness and cardiac remodeling in female hypertension patients.

Design and method:

One hundred and forty hypertensive patients provided written informed consent. Eligible participants were men and women aged 45 to 65 years old who had hypertension. Some indicators of the cardiac anatomy structures, the cardiac functionwere measured by M-mode echocardiography, two-dimensional echocardiography, doppler echocardiographic determination and tissue Doppler imaging. The SphygmoCor Vx Pulse Wave Velocity System was used to measure the carotid and femoral artery pulse wave velocity (cf-PWV). For testing the primary hypothesis, the efficacy analyses for the primary outcome were conducted according to the ITT principle.

Results:

There was a strong relationship between cardiac remodeling and correlation index of arteriosclerosis. In the following cases, we can see the same relationship: in the male and female patients, with the increase of augmentation index (AIx), ejection fraction (EF) were significantly increased (P < 0.001). in the females, AIx increase value, the decrease of ankle brachial index (ABI) and PWV rised with left ventricular end-diastolic dimension (LVDD), end-diastolic volume (EDV) and left ventricular mass index (LVMI) decreasing in patients (P < 0.05). in the male patients, the level of aortic artery systolic blood pressure (ASP) and cardio-ankle vascular index (CAVI) also raised with the rising of LVDD, LVMI and interventricular septal diastolic thickness (P < 0.05).

Conclusions:

In female patients with hypertension, the characteristic of cardiac remodeling is the decrease of LVDD. But in male patients, LVDD increasing is the main characteristic. It is still necessary to detect the sex hormones, in order to confirm the differences characteristic of cardiac between males and females are related to them.

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