PS 17-49 NOCTURNAL HYPERTENSION IS CORRELATED WITH ALBUMINURIA AND ESTIMATED GLOMERULAR FILTRATION RATE

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Abstract

Objective:

Nocturnal non-dipping (ND) is closely associated with target organ damage and cardiovascular events. We performed this study to further ascertain the association between nocturnal blood pressure and estimated glomerular filtration rate (eGFR) and albuminuria.

Design and method:

We enrolled 968 patients who were excluded with renal replacement therapy. Blood pressure (BP) values were acquired from ambulatory BP monitoring. The dipper pattern of BP was defined as 10% to 20% reduction of the mean systolic BP (SBP) values at night compared with the daytime values. The eGFR was calculated using serum creatinine according to the CKD-EPI equation adjusted for age, sex and race.

Results:

Non-dipper and reverse-dipper group had lower eGFR than those in dipper group (64.3, 55.6 vs. 71.1, p < 0.001). By Spearman's correlation analysis, mean SBP at night correlated significantly with mean SBP at the daytime (r = +0.676, p  < 0.001), age (r = +0.115, p  < 0.001), glucose levels (r = +0.100, p = 0.001 and albuminuria (r = +0.233, p  < 0.001). eGFR (r = −0.188, p  < 0.001), total cholesterol level (r = −0.067, p = 0.032), and hemoglobin (r = −0.138, p < 0.001) had a significant correlation with mean SBP at night. According to multivariable linear regression analysis, mean SBP at the daytime, age, albuminuria and eGFR were the independent risk factors affecting mean SBP at night.

Conclusions:

Our data support that eGFR and albuminuria are potential risk factors of nocturnal hypertension.

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