PS 17-63 A MULTICENTER COHORT STUDY OF PRIMARY HYPERTENSION IN KOREA; DESIGN AND INTERIM ANALYSIS OF THE KOREAN REGISTRY OF TARGET ORGAN DAMAGES IN HYPERTENSION (KorHR)

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Abstract

Objective:

The Korean Registry of Target Organ Damages in Hypertension (KorHR) aims to evaluate the characteristics and prevalence of clinical and subclinical target organ damages in Korean hypertensives.

Design and method:

This is a prospective observational multicenter cohort study, in which 15 university hospital participated. Since March 2013, we have enrolled 1318 consecutive hypertensive patients if 1) they are older than 30 years old, and 2) their first visit to participating hospitals was within last 5 years. We have excluded hypertensive patients with past history of atherosclerotic cardiovascular disease, heart failure, and chronic kidney disease.

Results:

The mean age was 52 ± 12 years; 62% were male; and 46% were incident hypertensives. Patients with diabetes mellitus were 7.8% and 44% had hyperlipidemia or were on statins at enrollment. Mean office blood pressures were 152 ± 19/96 ± 14 mmHg for incident hypertensive and 129 ± 13/78 ± 10 mmHg for patients on treatment. Patients with electrocardiographic and echocardiographic left ventricular hypertrophy were 19% and 27%, respectively. Mean brachial to ankle pulse wave velocity was 1559 ± 285 m/s. Patients with microalbuminuria and chronic kidney disease were 22% and 3.8%.

Conclusions:

Our interim analysis shows that subclinical target organ damages of hypertension are prevalent in incident or on-treatment hypertensives. These findings suggest that effort of finding subclinical target organ damages in hypertensive patients is important in the management of hypertension.

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