PS 17-80 DIFFERENCE OF METABOLIC DISTURBANCE IN POSITIONAL AND NON-POSITIONAL OBSTRUCTIVE SLEEP APNEA SYNDROME

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Abstract

Objective:

It is well known that obstructive sleep apnea-hypopnea syndrome(OSAHS) is associated with impaired glucose intolerance. We investigated that pattern of impaired glucose intolerance differs among patient with non-positional OSAHS and positional OSAHS.

Design and method:

We diagnosed OSAHS by overnight polysomnography study. And we assessed severity apnea-hypopnea index (AHI) and positonal apnea-hypopnea index difference. We defined positional OSAHS when supine-lateral index [(supine AHI- lateral AHI)/supine AHI] is more than 0.5. Insulin resistance was assessed with fasting plasma blood glucose, plasma insulin and homeostatic model assessment of insulin resistance index (HOMA-IR), leptin.

Results:

The respiratory disturbance index and lowest oxygen desaturation were higher in non-positional OSAHS group than positional OSAHS group. There were noted that impaired glucose tolerance and HOMA-IR were more increased in patient with severe OSAHS than control group and mild OSAHS. Compared with postional and non-positional OSAHS patients, impaired glucose tolerance and HOMA-IR were significantly increased in non-positional OSAHS group.

Conclusions:

Our result suggest that severe OSAHS is associated with glucose intolerance and non-positional OSAHS has a poor control of glucose than positional OSAHS group.

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