PS 18-17 effect of salt intake to nocturnal blood pressure in hypertensive patients administered angiotensin converting enzymes (ace) inhibitors

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To know the effect of low salt intake to nocturnal blood pressure in hypertension patient administered with ACE Inhibitors.

Design and Method:

This is a cohort prospective study which conducted to 30 – 50 years old ambulatory patients diagnosed as untreated hypertension, divided into two groups (low salt intake (Na <15 grams/day) and high salt intake (≥15 grams/day). Both of groups were administered Lisinopril 10 mg initially, underwent 24-hours sodium urine collection and home blood pressure monitoring periodically, and observed for 1 month.


There are 80 ambulatory patients diagnosed as untreated hypertension, consist of 37 patients in low salt intake group and 43 patients in high salt intake group. Low salt intake group has lower nocturnal systolic (p < 0.001), diastolic (p < 0.001), and mean arterial (p < 0.001) blood pressure compared with high salt intake group in the same of drug's dose administration. Mean salt intake in this study was 16.77 grams/day. Multivariate analyzes showed that the difference of decreasing nocturnal blood pressure was not interfered by age, sex, dyslipidemia, BMI, and sleep duration.


The present study has proved that low salt intake may interfere ACE Inhibitors therapy effectiveness in decreasing nocturnal blood pressure.

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