LBPS 02-01 ASCENDING AORTA ELASTICITY AND RELATED RISK FACTORS STUDY ON EARLY STAGE HYPERTENSION PATIENTS

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Abstract

Objective:

to discuss the characteristic of ascending aorta elasticity derived from coronary CTA for specific early stage hypertension patients and its risk factors

Design and method:

398 participants underwent coronary CTA examinations using a 128 slicer CT scanner. Images were automatically reconstructed at every 5% absolute phases in the entire R-R interval. The differences of three vascular elasticity indices including aortic distensibility (AD), aortic compliance (AC) and aortic stiffness (ASI) were analyzed among the normal blood pressure, early stage hypertension and primary hypertension groups

Results:

Normalized cross-sectional area for the ascending aorta was found significant lower in early stage hypertension group than that of primary hypertension group, but no difference was seen for normalized diameter. Also, no significant difference was found for and between early stage hypertension group and normal group. AD, AC and ASI were significantly different in three comparison groups. Pair-wise study indicated that between early stage hypertension and normal groups, AD and AC were found much smaller but no difference were found for ASI; while between early stage hypertension and primary hypertension groups, AD and ASI were found significantly different but not for AC. Risk factor study for early stage hypertension patients indicated that AD was significant different between smoking and non-smoking groups. Linear correlation coefficient between AD and age, Ps, dp, and glycosylated hemoglobin were −0.69 (P < 0.001), −0.37 (P < 0.001), −0.43 (P < 0.001) and −0.43 (P < 0.05) respectively. Age and Ps were the independent risk factors for AD decline.

Conclusions:

It is proofed that the early detection of aortic elasticity index changes, especially for AD and its risk factors, are essential for identifying the high risk individuals in the early stage hypertension populations

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