LBPS 02-08 EFFECTS OF BENDIPINE HYDROCHLORIDE ON 24-HOUR BLOOD PRESSURE MONITORING IN ELDERLY PATIENTS WITH ESSENTIAL HYPERTENSION

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Abstract

Objective:

To study the effect of a new dihydropyridine calcium antagonist, Long acting T,L and N channel blocker bendipine hydrochloride, on 24-hour blood pressure monitored by Ambulatory Blood Pressure Monitoring in real world elderly users.

Design and Method:

Ten elderly patients with essential hypertension (mean age: 65+/−5 years; 6 male and 4female). Subjects served as control for themselves from one month before starting therapy to be tested. After a control period of 4 weeks, 4 mg bendipine has been administered once daily in the morning for 12 weeks. Ambulatory blood pressure has been monitored using a non-invasive automatic portable device with the cuff-oscillometric method at the end of both the control and treatment periods.

Results:

Bendipine administration significantly has decreased 24-hour blood pressure, with a little insignificant ±change in heart rate. Daytime blood pressure decreased significantly, from 152.2 ± 10.5/90.8 ± 6.8 to 130.8 ± 8.2/81.5 ± 9.8 mmHg. However, no significant decrease in nighttime diastolic blood pressure is noted, and the decrease in nighttime systolic blood pressure has remained small (from 130.8 ± 8.9/76.1 ± 6.6 to 120.8 ± 9.1/73.7 ± 8.1 mmHg). No significant changes were observed in diurnal variability of blood pressure and heart rate. The decrease in systolic blood pressure by bendipine administration showed a significant positive correlation with systolic blood pressure before treatment in the 24-hour and daytime periods. Single cosinor analysis showed that bendipine administration significantly decreased MESOR of both systolic and diastolic blood pressure, without an increase in amplitude. The change in acrophase was not significant.

Conclusions:

These findings indicate that administration of bendipine once daily in the morning effectively decreases blood pressure. Neither reflex tachycardia, nor excessive lowering of nighttime blood pressure has been observed after bendipine administration. No significant deterioration of diurnal blood pressure noticed. It is suggested that bendipine is a potent and long-lasting antihypertensive medication

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