LBPS 02–13 EFFECT OF BENDIPINE HYDROCHLORIDE, A LONG-ACTING T-TYPE CALCIUM CHANNEL BLOCKER, AS A MONO-THERAPY IN DIABETES WITH HYPERTENSION

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Abstract

Objective:

The study was planned to find out the efficacy and safety of the drug in elderly as monotherapy

Design and Method:

Forty hypertensive patients with diabetes and poor BP control were selected, and the changes in BP and urine protein (UP) scores were investigated retrospectively after initiating benidipine 8 mg for more than 3 months

Results:

Both systolicand diastolic blood pressor was decreased significantly from 165.8 +/− 11.7 mmHg/86.5 +/− 10.3 mmHg to 140.9 +/− 13.0 mmHg/71.4 +/− 11.7 mmHg after bendipine treatment, and this effect was stably maintained for whole study period. Urinary Albumin also significantly decreased from 1.10 to 0.57 in the mean score. The decrease in Urinary albumin may be explained by a mechanism other than BP lowering effect.

Conclusions:

These results demonstrate that bendipine has an potent antihypertensive effect and also a renoprotective effect, indicating the high usefulness of bendipine in hypertensive patients with diabetes. T-type calcium channel blockade was suggested to be possibly involved in the renoprotective effect of bendipine.

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