To reveal influence of thrombolytic therapy on spectral shifts in blood serum in patients with myocardial infarction by mean of laser correlation spectrometry.Design and Method:
100 patients with myocardial infarction (MI) were examined according to ESH/ESC 2013 recommendations in the Odessa University Clinic. Their mean age was 59.8Y±5.2 years. They were divided into 2 groups: 1st group consisted of patients who received thrombolytic therapy (TT) during 30 minutes - 3 days from MI development (nY=Y64) and 2nd group was not prescribed TT (nY=Y36). In the 1st group alteplase was given to 39 patients and streptokinase to 25. Special investigation method was laser correlation spectrometry (LCS). Blood serum was an investigated biomaterial. Data were processed with biostatistics methods.Results:
In the patients who were prescribed TT according to LCS autoimmune shifts were prevailing (41%). They are correspondent to high-molecular particles with hydrodynamic radius more than 150 nm which are represented with immune complexes. Other alterations in reactions were the following (in decreasing order): allergy-like (15%), catabolic (13%), autoimmune-intoxication (9%). Summary amount of anabolic type made 56%. In the 2nd group where TT was not given autoimmune reactions were determined 1.5 times less than in the 1st group (27.3%). Contributions of other spectral reactions in descending order in these patients were: allergy-like reactions (15%), dystrophic (12%), catabolic (12%), intoxication (11%), autoimmune-intoxication (12%). Though, total amount of hydrolytic type was 35%.Conclusions:
In patients with MI who received TT in LCS anabolic spectral directions are prevailing over hydrolytic shifts due to autoimmune reactions. While in those patients who were not prescribed TT hydrolytic spectral directions are more presented. LCS is rather sensitive method in reflection of homeostatic alterations associated with treatment influence.