To evaluate spectral alterations in patients with complicated and non-complicated myocardial infarction (MI) for early diagnostics improvement.Design and Method:
100 patients were examined according to ESH/ESC 2013 recommendations in Odessa University Clinic in the first 6 hours after beginning of MI. Their average age was 57.1 ± 5.4 years old. They were divided into 2 groups. The 1st group included patients with non-complicated MI (n = 67) and the 2nd group consisted of patients with MI complicated by cardiac shock (CS); (n = 23). Laser correlation spectrometry was used for estimation of spectral shifts of blood serum in the first 6 hours. Biomaterial was taken before thrombolytic therapy.Results:
In the first 6 hours in the 2nd group hydrolytic shifts (dystrophic and catabolic-like reactions) were observed in 87% of patients. These changes either accompanied development of CS or preceded it (in 4 cases). In comparison with the 1st group these hydrolytic alterations were twice increased in the 2nd group with CS (41 vs 23%). Anabolic shifts (autoimmune reactions) were prevailing in the 1st group over the 2nd one (51 vs 38%). Mixed shifts contributed in blood serum content almost identically in the patients with complicated and non-complicated MI (16 vs 14%). Normological shifts were revealed two times more often in the 1st group then in the 2nd one (12 vs 5%).Conclusions:
Thus, possible development of cardiac shock may be determined by the level of necrotic processes in myocardium which is reflected in LCS alterations as prevailing of dystrophic and catabolic-like reactions in serum content. These spectral changes in the serum according to LCS data can be a predictor of the complicated flow of MI.