Adrenal vein sampling (AVS) is the only reliable means to distinguish between aldosterone-producing adenoma and bilateral adrenal hyperplasia, the two most common subtype of primary aldosteronism (PA). A rare but serious complication of AVS is an adrenal hemorrhage (AH).Design and Method:
We retrospectively evaluated 24 cases of AH after AVS that occurred in 6 tertiary referral hypertension centers in Italy, Germany, Japan and Australia. The control group comprised 1388 PA patients who underwent AVS in the different centers participating in the study during a similar period of time as when the patients experienced AH during AVS.Results:
In our case-series, AH more often affected the right adrenal (nY=Y18) than the left (nY=Y5, PY
In conclusion, AH usually has a positive outcome and AVS should remain the preferred approach to subtype differentiation in PA patients.