Madura island has highest incidence of periodontal disease due to poor oral hygiene. Porphyromonas gingivalis and Treponema denticola, two pathogens commonly found in Madureses’ oral cavities, are believed to have close association with hypertension and cardiovascular disease. Hereby, we aimed to analyze the associations between periodontal disease and the incidence of early onset hypertension among young indigenous peoples on Madura island.Design and Method:
Retrospective cohort study was conducted between January-April 2016 in 8 community health care on Madura Island, collecting 413 indigenous Madurese population, aged 30–49 years old, consists of 204 (49.39%) hypertension subjects and 209 (50.61%) healthy subjects. No statistically difference between mean age, gender ratio, total daily intake, sport habit, smoking, diabetes, and hypercholesterolemia in both groups. Evaluation of anaerobic pathogens used salivary cultures using OMIZ-W1 medium.Results:
Hypertension groups showed higher prevalence of periodontitis compared to healthy groups (0.42 ± 0.05 vs 0.19 ± 0.04, p < 0.0001). The presence of anaerobic pathogens Porphyromonas gingivalis (0.73 ± 0.12 vs 0.53 ± 0.26, p = 0.008) and Treponema denticola (0.59 ± 0.19 versus 0.36 ± 0.29, p = 0.012) were recorded higher in hypertension groups.Conclusions:
The presence of Porphyromonas gingivalis and Treponema denticola in periodontal disease is a risk factor of early onset hypertension and early changes in the peripheral blood vessels among Madurese population. Moreover, improving oral hygiene among indigenous Madurese population has protective effects in hypertension and peripheral vascular remodelling.