[OP.2C.06] NEW RISK FACTORS FOR ATRIAL FIBRILLATION IN PATIENTS WITH HYPERTENSION AND OBESITY

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Abstract

Objective:

Hypertension (HT) and obesity (OB) are the most common causes of non-valvular atrial fibrillation (AF). Study objective was to evaluate the role of profibrogenic factors such as galectin 3 (GAL3) and aldosterone (ALDO) in the onset of atrial fibrillation (AF) in patients with HT and OB.

Design and method:

100 patients 35–65 years old with HT and OB including 50 patients with new onset of AF were examined. The control group was 50 healthy persons without cardiovascular disease. Groups did not differ significantly by gender, age, eGFR (p > 0,05). The examination includes: medical history, anthropometry, echocardiography, serum GAL3 and ALDO (Enzyme immunoassay). Patients with hyperaldosteronism were excluded.

Results:

GAL3 in patients with HT, OB and AF was more than 2 fold higher than in healthy control (0.72 [0.44;1.36] and 0.32 [0.28;0.42] ng/ml; p < 0,001), and it was higher than in patients with HT, OB without AF (0.72 [0.44;1.36] and 0.44 [0.42;1.22] ng/ml; p < 0,01). ALDO was significantly higher in group of patients with HT, OB and AF, than in HT, OB patients without AF and higher than in healthy control (202.2 ± 82.5 and 150.3 ± 72.2 and 98.4 ± 51.8 pg/ml; p < 0,001). Statistical analysis was showed a positive correlation between GAL3, volume and index of volume left atrium (r = 0.45, r = 0.39; p < 0,001). GAL3 was positive correlated with waist circumference, systolic blood pressure, triglycerides and fasting glucose (r = 0,57; 0,51; 0,41; 0,40, p < 0.001) and negative correlated with HDL cholesterol (r = − 0,43, p < 0.001). Serum ALDO was also positive correlated with volume and index of volume left atrium (r = 0.38, r = 0.32; p < 0,001). Multivariate logistic regression analysis identified that the GAL3 (OR = 1.27, 95% CI 1.02–1.6, p < 0.001) and ALDO (OR = 1.11, 95% CI 1.08–1.18, p < 0.001) - an independent risk factors of AF in patients with HT and OB.

Conclusions:

The markers of fibrosis galectin 3 and aldosterone in patients with hypertension, obesity and atrial fibrillation were higher than in patients without arrhythmia and much more higher than in healthy persons. Galectin 3 and aldosterone were correlated with the parameters of remodeling left atrium and associated with higher risk of atrial fibrillation in patients with hypertension and obesity.

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