[OP.LB03.08] EFFECTS OF LTP2 PEPTIDE RICH WHEAT PRODUCTS ON BLOOD PRESSURE, ENDOTHELIAL REACTIVITY AND OTHER CARDIOVASCULAR RISK FACTORS: A DOUBLE-BLIND, CROSS-OVER, RANDOMIZED CLINICAL TRIAL

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Abstract

Objective:

Different wheats contain different amounts of bioactive peptides and with different pharmacological effects. Some wheat peptides as LTP2 have known ACE-inhibitory activity in vitro. Our aim was to test the haemodynamic and metabolic effect of two kind of commercial wheat product made by wheat naturally containing a high (Khamut®) or low amount of LTP2.

Design and method:

Methods: in the context of the 7FP EU “Beneficial Effects of Bioactive Compounds in Humans (BACCHUS)” project, we enrolled 60 non-diabetic subjects (age 40–70 years old), at increased estimated CV risk (ESC/EAS SCORE), with SBP 130–139 mmHg and/or DBP 85–90 mmHg (pre-hypertensive/borderline high pressure subjects), in primary prevention for CVD, and we randomized then to the two experimental arms. The trial was a double-blind, cross-over, randomized clinical trial. Each treatment phase had a 4-week duration.

Results:

Anthropometric parameters, office blood pressure, cholesterol, liver and renal parameters did not change during both wheat products intake.

Results:

Diurnal and nocturnal systolic blood pressure significantly improved only after Khamut intake versus baseline and versus control (from 136,3 ± 4,2 to 132,4 ± 4,5 mmHg, p < 0.05, and from 120,8 ± 5,4 to 116,4 ± 4,1 mmHg, p < 0,05, respectively).

Results:

Pulse volume change (as a marker of endothelial reactivity) significantly improved only after Khamut intake versus baseline and versus control (from 64,3 ± 6,6 to 68,1 ± 4,2, p < 0.05).

Results:

Pulse wave velocity and augmentation index did not change during both wheat products intake.

Results:

Plasma fasting triglycerides and glucose significantly improved only after Khamut intake versus baseline and versus control (from 123,5 ± 32,9 to 107,2 ± 21,5 mg/dL, p < 0.05, and from 86,3 ± 8,8 to 84,2 ± 6,3 mg/dL, p < 0,05, respectively).

Conclusions:

Substituting standard wheat products in diet with products rich in LTP2 peptide seems to mildly improve 24-hour systolic blood pressure, endothelial reactivity, fasting triglycerides and glucose level in overall healthy subjects with suboptimal blood pressure control.

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