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Central blood pressure (CBP) measurement might precise the individual cardiovascular risk of the patient. We sought to evaluate the accuracy of the CBP calculation with a new oscillometric device Tel-O-GRAPH® (I.E.M., Stolberg, Germany) in different common clinical situations.103 subjects were prospectively included in the study. The performance accuracy of Tel-O-GRAPH® was assessed in comparison to Sphygmocor® (AtCor Medical, West Ryde, NSW, Australia) using Bland-Altman approach. The robustness of the values with Tel-O-GRAPH® was evaluated in supine and seated positions as well as for experienced and inexperienced user.Mean age of the study population was 60 ± 17.9 years. 56.6% were male and mean BMI was 26.5 ± 4.9 kg/sqm. The mean systolic CBP was 126.7 ± 21.9 mmHg measured with Tel-O-GRAPH® and 126.6 ± 22.5 mmHg measured with Sphygmocor®. Good agreement between Tel-O-GRAPH® and Sphygmocor® for CBP could be shown (mean -0.3 ± 6.7 mmHg; Person's r = 0.95; p < 0.0001). The mean difference of CBP with Tel-O-GRAPH® was 1.5 ± 6.8 mmHg (r = 0.9; p < 0.0001) and -1.4 ± 5.0 (r = 0.97; p < 0.0001) mmHg between supine vs. seated position and between experienced vs. inexperienced user respectively.Tel-O-GRAPH® calculates CBP easy and quickly using “one button press” procedure. We observed a high CBP measurement accuracy compared to Sphygmocor®. Given stable brachial blood pressure measured CBP values seem to remain robust independently of body position or operator experience.