To examine arterial stiffness andnight-timeblood pressure (BP) reductionin patients (pts) with essential arterial hypertension (AH) after transient ischemic attack (TIA).Design and method:
The study included 80 pts with AH grade I-II. The main group included 40 individuals with AH after TIA in previous 1 - 6 months. Mean age of thepts was 59.0 ± 1.52 years. The control group consisted of thepatients with uncomplicated AH. Mean age of the control group pts was 58.3 ± 2.5 years. The study groups did not differ by age, sex, duration of AH, body mass index and smoking. Ambulatory BP monitoring was performed using the standart protocol. Applanation tonometry performed to define arterial stiffness including central pulse pressure (CPP), augmentation index (AI), carotid femoral pulse wave velocity (PWV) by«SphygmoCor» device. All patients were taken a complete cholesterol test.Results:
The «non-dipping» and «night-peaker» systolic BP profiles had 13 pts (33%), 3 pts (8 %) and similar diastolic BP profiles – 13 pts (33%), 1pts (3 %) of the main group, respectively, without statistical differences of the control group pts. CPP washigher in hypertensive pts with TIA compared with uncomplicated hypertensive pts (58.1 ± 1.5 mmHgvs 46.0 ± 2.1 mmHg, p < 0.05). There were obtained that AI differed between the main and control groups of pts (-7.4 ± 2.7% and -25.9 ± 4.5%, p < 0.001). PWV was higher in pts after TIA compared to ptswith uncomplicated AH (9.8 ± 0.14m/secvs 8.4 ± 0.11 m/sec, p < 0.05). According to the blood lipid test differences were observed only on the levels of triglycerides between the two groups:1,9 ± 0,1 mmol/l in the group of pts with TIA and 1,4 ± 0,1 mmol/l in the control group of pts (p < 0.02).Conclusions:
Increased arterial stiffness and high level of triglycerides can be additional risk factor for TIA development in hypertensive pts.