[PP02: 01] CENTRAL AORTIC PRESSURE IS INDEPENDENTLY ASSOCIATED DIASTOLIC FUNCTION IN CHINESE ELDER COHORT

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Abstract

Objective:

Study investigated the association between various noninvasive indexes of artery stiffness and left ventricular diastolic function.

Design and method:

Two-dimensional, color and tissue Doppler echocardiography and radial artery tonometry were performed simultaneously in 1599 Shanghai community elder cohort. Brachial systolic (bSBP), pulse pressure (bPP), central systolic (cSBP), pulse pressure (cPP) and augmentation pressure (AP) were entered individually into stepwise linear regression models to determine their association with left ventricular filling pressure (E/Em).

Results:

In the various index of artery stiffness, between the brachial and central blood pressure, only the cSBP and cPP were independent association with left ventricular diastolic function (E/Em) (p < 0.001,respectively). But the pulse wave velocity (PWV) and brachial hemodynamic was not significant association with E/Em in the stepwise multiple linear regression. In the multiple linear regression by adjusting for the central SBP, PP, AP, and potential confounding covariates of LV diastolic function, only the central PP was independent related to the diastolic pressure (p < 0.001). All the results was similar in all the subgroup analyses by dividing into men, women, and untreated subject (without anti-hypertention treatment).

Conclusions:

In the Chinese elderly cohort, the central hemodynamics was superior to the brachial and PWV in reflecting left ventricular diastolic function. Among the central hemodynamics (SBP, PP, AP), the central PP was were most strongly associated to the diastolic function. This result suggested that the central PP maybe the better treating index in the diastolic heart failure treated.

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