Research objective was studying of the PWV features at male patients with essential hypertension (EH) stage I-II and moderate and severe cardiovascular risk.Design and method:
It were surveyed 128 male patients with EH of 1–3 degrees. All patients were divided into 3 groups after stratification of risk factors for cardiovascular disease: IA group (n = 22) – patients with EH stage I and moderate CV risk; IB group (n = 22) - patients with EH stage I and high CV risk; II group (n = 84) - patients with EH stage II and high CV risk. It were investigated 2 diagnostic thresholds for detection of arterial stiffness: PWV normal level < 10 m/s and the individual threshold of PWV depending on age and hypertension grade [Arterial Stiffness’ Collaboration, 2010], which was the normal (in the range of 10th percentile - median) and high normal PWV (above median). Clinical characteristics of the observed groups are presented at the table 1.Design and method:
All results per category are represented as mean ± SEM (m) and median (25th to 75th percentile).Design and method:
Measurement of PWV was carried out using the device Arteriograph TensioMed (TensioClinic, Hungary).Results:
PWV level in IA group was 7,15 (6,38; 7,70) m/s, PWV high level frequency registered in 11 (50%) patients according to age and blood pressure level. In IB group PWV value was 8,10 (7,23; 8,53) m/s, PWV high level frequency registered in 17 (77.3%) patients according to age and blood pressure level. In II group PWV value was 9,85 (8,5; 10,9) m/s and in 42 patients (50%) PWV level increased more than 10 m/s, that was testified to the target organ damage. In 22 male patients from the II group (26,20%) was individual increasing of PWV according to age and blood pressure level.Conclusions:
The detected signs of arterial wall stiffness in patients with early stage of EH indicate increasing of cardiovascular risk severity and necessary for timely evaluation of pulse wave velocity for the early identifying of premature vascular aging.