The aim of this study was to determine difference of the cardiovascular risk (CVR) in young women with essential hypertension (H) and postsurgical or early physiological menopause (M), and evaluation possibility of correction due to menopausal hormone therapy (MHT).Design and method:
Were examined 112 women with H, the average age 43 years with menopause from 2 to 5 years, which formed 3 groups: 1 group included 37 patients with H and postsurgical M which not prescribed MHT; 2 group included 37 patients with H and postsurgical M which was appointed low-dose combination of estrogen and progesterone MHT for prevent postcastration symptoms. The 3 group included 38 patients with H and early physiological M without MHT. All patients performed physical, instrumental, laboratory research and ultrasound examination with the definition of the intima media complex thickness (IMT) of carotid arteries. Was calculated CVR according to standard SCORE, also scale with body mass index - SCORE-BMI and based on registration the IMT - SCORE-IMT.Results:
Patients of 2 group with MHT set significantly (P < 0,01) more optimal circadian blood pressure profile, glycemic and lipid profile than at patients 1 and 3 groups. In the 2 group as compared to 1 and 3 groups was significantly less (P < 0,01) IMT and were less (P < 0,01) detected atherosclerotic plaques. All SCORE scales showed a lower risk in group 2, but the most impressive was the reduction in the risk according to SCORE-IMT (P < 0,001), which demonstrated the possibility of preventing atherosclerotic lesions in patients with postsurgical M who received MHT.Conclusions:
In young patients with H and postsurgical M or early physiological M demonstrate pro-atherogenic changes. Appointment of MHT at patients with postsurgical M may not only optimize the antihypertensive effects but also prevent the manifestation of atherosclerosis.