[PP.03.22] BODY IRON STORE IN POLYCYSTIC OVARY SYNDROME ASSOCIATED TO WEIGHT EXCESS

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Abstract

Objective:

study the impact of the association polycystic ovary syndrome (PCOS) and weight excess on body iron store and analyze correlations between body iron store and insulin resistance, adiposity, subclinical inflammation, and steroidogenesis.

Design and method:

A total of 85 women were explored and classified depending on the presence or the absence of PCOS, and/or weight excess. Serum hormones, lipids, sugar, high sensitive C reactive protein iron, and ferritin were analyzed. All statistical analyses were conducted with SPSS software. P < 0.05 was considered significant.

Results:

Serum ferritin concentrations were increased in women with PCOS, and manly when weight excess was associated. In women with isolated weight excess, a significant positive correlation between high-sensitive C-reactive protein and body mass index in the one hand, and ferritin in the other hand, were noted. In women with PCOS associated to weight excess, a significant negative correlation between 17 hydroxy-progesteron and ferritin was observed.

Conclusions:

Iron metabolism modifications observed in PCOS associated to weight excess would flow metabolic pathways distinct from those followed in isolated PCOS or weight excess. Steroidogenesis would be a key factor with a probably adipokine involvement.

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