[PP.03.26] ESTIMATION OF NT-PROBNP LEVEL IN RUSSIAN POPULATION

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Abstract

Objective:

NT-proBNP is one of the factors associated with prognosis in patients with cardio-vascular (CV) diseases but only few data was received in population-based epidemiological studies. The aim of our study was to appreciate NT-proBNP level and its association with other CV risk factors on populational level.

Design and method:

As a part of all-Russian epidemiology survey ESSE-RF random sampling of 1600 Saint-Petersburg inhabitants (25–65 years) stratified by age and sex was involved. All subjects signed informed consent and filled in questionnaire regarding risk factors, diseases and concomitant medication. Anthropometry (weight, height with body-mass index (BMI) calculation, waist circumference (WC)), blood pressure (BP) measurement and fasting blood-tests: glucose, lipids, NT-proBNP (Abbott Architect 8000 (USA) were performed. Hypertension was diagnosed in BP>140/90 mmHg or antihypertensive therapy. Daily intake of pickled products or food over salting were assumed as high salt intake. Logistic regression was performed using SPSS Statistics 20.

Results:

No gender differences in NT-proBNP mean values were found out. Elevated NT-proBNP >125 pg/ml was detected in 144 (9,1%) and >300 pg/ml – in 25 (1,6%) subjects. Results of association with traditional risk factors are presented in the Table 1.

Conclusions:

Hypertension was revealed as the most relevant risk factor associated with elevation of NT-proBNP independently of age, gender or obesity. Elevated salt consumption on population level increases probability to have elevated NTproBNP.

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