[PP.03.30] CENTRAL BLOOD PRESSURES AND ARTERIAL STIFFNESS ARE MUCH HIGHER IN HYPERTENSIVE WOMEN WITH MORE CARDIOVASCULAR RISK FACTORS DESPITE ADEQUATE TREATMENT

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Abstract

Objective:

The high central pressure is an indicator of vascular risk, especially when they are higher than expected in hypertensive patients (HP). Despite various studies, few data has been written regarding PH who also have more cardiovascular risk factors (CVRF) in addition to high blood pressure (HTA) and are women. In the present study, we show the values of central pressures in hypertensive women without other CVRF compared with those who have more than 1 CVRF besides hypertension.

Objective:

Objectives: prospective observational open-label study to assess central systolic and diastolic pressures (CSBP, CDBP) and arterial stiffness of large and small vessels in women with hypertension without CVRF compared with those with more than one CVRF and well controlled HTA with peripheral measurements.

Design and method:

We studied two groups: Group A: 45 women without other CVRF HP (53 ± 6 years, BMI< = 25) and compared to Group: 65 women with hypertension and more than 1 CVRF (55 ± 4 years). We included only those taking ACE inhibitors, ARBs and diuretics to keep blood pressures (BP) below 140/90 in peripheral BP controls performed by their doctor. Not receiving other antihypertensive treatments were included. In all patients we studied CSBP, CDBP, augmentation index (AI) as well as the pulse wave velocity (PWV) and total peripheral vascular resistance (TPR).

Results:

The results were compared and are shown in the following table:

Results:

* mean p < 0.05

Conclusions:

According to our study, hypertensive women with more risk factors have the central pressures significantly higher than women without other CVRF, despite adequate control of peripheral arterial pressures, also presenting a much more higher arterial stiffness data at the level of small and large arteries, indicating that the approach to these patients must be done in a comprehensive manner and not only to the control of hypertension, to reduce vascular risk. There is also a tendency to show higher TPR although not significant in these patients.

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