[PP.03.32] ALCOHOL CONSUMPTION AND HYPERTENSION IN PATIENTS WITH PREVIOUS REVASCULARIZATION; A SUBSTUDY OF THE POP-HT STUDY

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Abstract

Objective:

The prognosis of patients (pts) after coronary artery bypass surgery (CABS) has been noted in many studies, but there were no studies which analyzed prognosis of light-to-moderate alcohol consumers with hypertension (HTA) after prior CABS. This substudy of POP-HT study (PostOperative Prognosis-HyperTension study), aimed to evaluating the influence of light-to-moderate alcohol consumption on the HTA expression in patients after prior CABS.

Design and method:

The effect of light-to-moderate alcohol consumption was assessed in 328 pts with HTA after prior CABS (post bypass group) and control group of 540 pts with HTA and without prior CABS, who were followed from April 1988 to December 2015.

Results:

At baseline post bypass group was slightly younger (p = 0.0402), with more men (p = 0.4450) and with more pts with previous angina (p = 0.0440) and previous AMI (p = 0.0389). Control group of pts had more hyperlipidemia (p = 0.0404). Other baselines characteristics were similar in both groups of patients. After adjustment for cardiovascular risk factors by logistic regression, alcohol consumption displayed a protective effect against HTA in post bypass group of patients, but not in control group of pts.

Conclusions:

The effect of light-to-moderate alcohol consumption is associated with decreasing risk of HTA in pts with prior CABS, but not in pts without prior CABS. This effect of light-to-moderate alcohol consumption is probably because of decreasing of cholesterol, triglycerides and fibrinogen, as well as physiological changes in coronary arteries and decreasing in sympathetic nervous system activity.

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