[PP.05.08] CHEMERIN IS INDEPENDENTLY ASSOCIATED WITH ALBUMINURIA AFTER ADJUSTING THE BLOOD PRESSURE IN TYPE 2 DIABETIC PATIENTS

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Abstract

Objective:

Chemerin may play an important role in the pathogenesis of obesity and insulin resistance. Moreover, chemerin levels show a significant correlation with blood pressure. Recently, chemerin levels were found to be significantly associated with renal dysfunction in type 2 diabetic patients. However, the relationship between chemerin and albuminuria is unidentified yet. We aim to determine whether serum chemerin levels are associated with albuminuria in type 2 diabetic patients.

Design and method:

One hundred two newly diagnosed type 2 diabetic patients were included. Blood pressure, body mass index (BMI), waist circumference (WC), serum concentration of chemerin, glucose, insulin, lipid profile, urine albumin excretion (UAE), glomerular filtration rate (GFR) and hsCRP were measured. Serum chemerin levels were measured by enzyme-linked immunosorbent assay.

Results:

Serum chemerin level had significant relationship with BMI (r = 0.343, p < 0.001), WC (r = 0.36, p = 0.001), insulin (r = 0.452, p = 0.000), triglyceride (r = 0.295, p = 0.003), HDL-cholesterol (r = -0.318, p = 0.002), hsCRP (log-transformed, r = 0.263, p = 0.037) and UAE (log-transformed, r = 275, p = 0.007). Moreover, after adjustment for blood pressure and glucose, multiple regression analysis showed that serum chemerin was significantly associated with UAE (β = 0.256, p = 0.011).

Conclusions:

Serum chemerin is an independent risk factor associated with albuminuria after adjusting the blood pressure in type 2 diabetic patients.

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