[PP.05.19] EFFECTS OF SGLT2 INHIBITORS ON BLOOD PRESSURE, BAPWV, CAROTID ARTERIAL IMT AND ELASTIC MODULUS IN TYPE 2 DIABETIC PATIENTS WITH OBESITY

    loading  Checking for direct PDF access through Ovid

Abstract

Objective:

We investigated the effects of SGLT2 inhibitors on blood pressure, baPWV,carotid arterial IMT and elastic modulus in type 2 diabetic patients with obesity.

Design and method:

The thirty-one patients with diabetes mellitus and obesity (average age: 53 years old, BMI31 kg/m2) were treated with SGLT2 inhibitors (one of the following drugs: Ipragliflozin, Dapagliflozin, Luseogliflozin, Tofogliflozin, Canagliflozin, Empagliflozin) for 12 months. Serum markers, office and central blood pressures and brachial-ankle pulse wave velocity (baPWV) were examined. The intima-media thickness (IMT) and elastic modulus in the circumferential direction (E θ) were simultaneously measured by the high-resolution Doppler technique, “Phased Tracking Method”.

Results:

The basal values of fasting blood sugar (FPG), HbA1c, body weight, TG, HDL-C, LDL-C, AST, ALT, γ-GTP, uric acid (UA), eGFR, office blood pressure (BP), pulse pressure, baPWV, central SBP (cSBP), IMT, E θ were the followings: 126 ± 30 mg/dL, 7.6 ± 1.5%, 87.9 ± 18.5 kg, 153 ± 39 mg/dL, 46 ± 10 mg/dL, 105 ± 31 mg/dL, 41 ± 34IU, 45 ± 28IU, 49 ± 40IU, 6.0 ± 1.0 mg/dL, 79.0 ± 20.8 ml/min./1.73m2, 131 ± 15/79 ± 9mmHg, 52 ± 10mmHg, 1618 ± 285 cm/sec, 136 ± 14mmHg, 1.34 ± 0.48 mm, 318 ± 89kPa. After 12 months of administration of SGLT2 inhibitors, FPG (-12%), HbA1c (-8%) and body weight (-2%) decreased significantly (p < 0.05). As for liver function, AST (-33%), ALT (-29%) and γ-GTP (-18%) also decreased significantly. No significant changes were seen in TG, HDL-C and eGFR. The drugs also decreased LDL-C (-10%), UA (-19%), office BP (-6%/-6%, cSBP (-8%), baPWV (-8%), IMT (-9%) and E θ (-23%) significantly. The histogram analysis of the E θ data revealed both of the drugs decreased harder components of the elasticity distribution, suggesting improvement of endothelial dysfunction.

Conclusions:

Our results indicate that SGLT2 inhibitors may have effects on blood pressure, IMT and E θ and baPWV to improve the distortion in the intramural elasticity distribution in arteries in type 2 diabetic patients with obesity. The measurement of the carotid elastic modulus may be useful to evaluate the efficacy of drugs for improving regional atherosclerotic changes.

Related Topics

    loading  Loading Related Articles