[PP.06.02] THE PREVALENCE OF RENAL DYSFUNCTION IN PATIENTS WITH ARTERIAL HYPERTENSION IN RUSSIAN POPULATION. BY THE DATA OF EPIDEMIOLOGICAL STUDY ECVD-RF

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Abstract

Objective:

Was used data from epidemiological study ECVD-RF (Epidemiology of Cardiovascular Diseases and their Risk Factors in Regions of Russian Federation) including adult population at the age of 25–64 y.o. of 10 regions RF (n = 16936, including 64% females and 36% males): Vladikavkaz, Volgograd, Vologda, Voronezh, Ivanovo, Krasnoyarsk, Orenburg, Samara, Tomsk, Tyumen.

Design and method:

Was used the systematic stratified multistage random sampling creating by the territorial principle of method by Keesh. Renal dysfunction was assessed on the basis of the calculation 0f glomerular filtration rate (GFR). GFR was conducted on the Chronic Kidney Disease Epidemiology Collaboration (GRF-EPI). Statistic data calculation was done with computer-based statistic software STATISTICA 10.0 and SPSS 14.0.

Results:

Final analysis included 15570 persons. The study reveals a high prevalence of GFR decline (< 90 ml/min/1,73 m2) in the population studied – 26,5%. According to the identification of chronic kidney disease (CKD) and minor renal dysfunction, these patients were divided into different groups. 1st group – persons with normal renal function 73,5%, 2nd group – patients with minor renal dysfunction (GRF 60–90 ml/min/1,73 m2) 25,4%, 3rd group – patients with CKD 1,1%. Among the patients with arterial hypertension (AH) CKD was found 3 times more often than without – 1,8% and 0,43% respectively, minor renal dysfunction was twice higher in patients with AH (34,8%), than without (16,2%). Systolic blood pressure was significantly higher in hypertensive patients (152,6 ± 21,4 mmHg) with renal dysfunction (p < 0,0001) than without (144,8 ± 17,9 mmHg). But diastolic blood pressure didn’t have differences. Antihypertensive treating was undergoing only 60% hypertensive patients 1st group, 70% – 2nd group and 80% – 3rd group. According multivariate analysis major risk factors associated with renal dysfunction (odds ratio) were hypercholesterolemia 1,92 (95% CI, 1,77–2,08), fasting hyperglycemia 1,63 (95% CI, 1,41–1,89) and systolic blood pressure 1,7 (95% CI, 1,56–1,88).

Conclusions:

Study results showed high prevalence of renal dysfunction in the investigated Russian population, especially among patients with AH. The large part hypertensive patients with renal dysfunction don’t have antihypertensive drugs. Therefore more careful outpatient observation for patients with AH is necessary.

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