[PP.06.16] THE RISK FACTORS OF CARDIOVASCULAR DISEASE IN PERSONS WITH HIGH NORMAL BLOOD PRESSURE IN RUSSIAN POPULATION BY DATA ESSE-RF

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Abstract

Objective:

To assess risk factors of cardiovascular disease in persons with high normal blood pressure.

Design and method:

In the framework of Multicenter observational study ESSE-RF (Epidemiology of Cardiovascular Diseases and their Risk Factors in Regions Russian Federation) by the protocol the investigation of representative selections of adult population at the age of 25–64 y.o. of 13 regions RF (n = 21887, males n = 8357).

Design and method:

Population-based cross-sectional study was conducted. Statistic data calculation was done with statistic software STATISTICA 10.0, SPSS 14.0.

Results:

Of the 21887 people who were screened 9586 (43,8%) had arterial hypertension (AH), 3387 persons (35,3%) didn’t take antihypertensive medications (AHM) and/or statins. Current analysis was included 7095 persons with normal BP (<129/84 mmHg) – first group; 2415 people with high normal BP (HNBP) (130–139/85–89 mmHg) – second group; 3387 untreated hypertensive persons: 2450 with AH grade I – third group, 698 with AH II– forth group and 239 with AH III– fifth group. In this group risk factors AH were assessed.

Results:

The persons with HNBP had statistical significant higher level cholesterol, LDL, TG and fasting glucose compared to the people with normal BP, and significant lower level then hypertensive patients. It was not statistical significant differences according the level HDL between the groups.

Results:

The patients of the 2-nd group had statistical significant (p < 0,0001) higher waist circumference (88sm), then group 1 (81 sm) and lower then 3–5 groups.

Results:

Family history was often (p < 0,0001) burdened in patients with AH unlike person with normal and HNBP.

Results:

The patients had diabetes mellitus (DM) in 1 group in 2,4% cases; and twice more often in 2-nd – 4,4% (p < 0,0001); 3-rd – 6,2%; 4-th – 8,2%; 5-th - 13%.

Conclusions:

Unfortunately a lot of hypertensive patients didn’t take AHM in the studied sample. The rate of persons with HNBP is quite large almost the same as patients with AH grade 1. At the same time the persons with HNBP had more metabolic disorders and DM compared with the group with normal BP. The results show that is necessary as early as possible to modify risk factors with persons with HNBP.

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