[PP.07.02] AMBULATORY SYSTOLIC-DIASTOLIC PRESSURE REGRESSION INDEX IS GENETICALLY DETERMINED IN HYPERTENSIVE PATIENTS WITH CORONARY HEART DISEASE

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Abstract

Objective:

The aim of this study is to report the relationship between certain single nucleotide polymorphisms (SNP) and ambulatory systolic-diastolic pressure regression index (ASDPRI) in patients with CAD confirmed by coronary angiography.

Design and method:

In the present study, 1345 subjects with CHD were included. SNPs were selected from genome-wide association studies published before June 2009, in which genome-wide association exceeded a threshold of p<5x10-8. Selected SNPs were reported to be associated with CAD risk. DNA was obtained from whole blood. The SNPs were genotyped using IPLEX reaction on a MassARRAY platform (Sequenom, San Diego, CA, USA). SNPs with a genotyping success rate was greater than 90% and minor allele frequency was greater than 5%. ASDPRI was calculated as one minus the slope of the linear relation between 24-hour DBP and 24-hour SBP. Daytime-nighttime ASDPRI variability was defined as the percentage decrease in mean ASDPRI during the nighttime (ASDPRI nighttime dipping) period and was calculated as 100 x [daytime ASDPRI mean – nighttime ASDPRI mean] / daytime ASDPRI mean].

Results:

There were significant differences in 24-hour and daytime and nighttime ASDPRIs for PHCTR1, LPA and ADAMTS7 polymorphisms. These polymorphisms were included in the analysis of covariance. Two out of three gene polymorphisms (LPA and ADAMTS7) as well as sex, age, BMI and diabetes were significantly related to 24-hour ASDPRI. There were significant differences in nighttime ASDPRI dipping for the PPAB2B, WDR12 and ADAMTS7 polymorphisms (table 1). Analysis of covariance revealed a significant relationship between the PPAB2B and WDR12 polymorphisms, sex, diabetes and nighttime ASDPRI dipping (table 2).

Conclusions:

In the present study, ADAMTS7 and LPA polymorphisms are related to 24-hour ASDPRI but PPAB2B and WDR12 gene polymorphisms are associated with nighttime ASDPRI dipping.

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