[PP.07.17] VITAMIN D RECEPTOR GENE POLYMORPHISMS, FGF-23 AND FETUIN-A IN ESSENTIAL HYPERTENSION

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Abstract

Objective:

The association between FokI and BsmI vitamin D receptor gene (VDR) polymorphisms and cardiovascular risk was analyzed with contrasting results. Low plasmatic concentrations of fetuin-A, a negative regulator of vascular calcification, and high levels of fibroblast growth factor 23 (FGF-23), a calcium and phosphate metabolism regulator, seem to be associated with higher cardiovascular mortality.

Objective:

Our aim was to evaluate possible association between FokI and BsmI VDR polymorphisms and plasma concentrations of fetuin-A and FGF-23 in essential hypertension.

Design and method:

Seventy-one patients with essential hypertension underwent clinical blood pressure evaluation, 24-hour ambulatory blood pressure monitoring, assays of 25-hydroxyvitamin D (25[OH]D), FGF-23 and fetuin-A serum levels, and FokI and BsmI VDR polymorphisms analysis.

Results:

No significant correlations were found either between 25[OH]D and FGF-23, or between 25[OH]D and fetuin-A. When patients were divided according to FokI and BsmI genotypes, we did not observe any significant difference in 25[OH]D, fetuin-A and FGF23 values among different subgroups. Considering FGF-23 median value (79 pg/ml), we did not find any association between a genotype or allele and FGF-23 serum level higher than cut-off. A similar result was obtained by evaluating the association between FokI and BsmI genotypes or alleles, and fetuin-A levels lower than median value (1,2 g/L).

Conclusions:

In essential hypertension FokI and BsmI VDR polymorphisms does not seem to be associated either with high FGF-23 serum levels, or with low fetuin-A plasma concentrations.

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