[PP.07.21] PARG GENE POLYMORPHISM IS ASSOCIATED THE DEVELOPMENT OF LEFT VENTRICULAR HYPERTROPHY IN ARTERIAL HYPERTENSION

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Abstract

Objective:

The purpose of the study was to investigate a possible association of polymorphic markers of the gene encoding nuclear receptor of PPAR family and nuclear proteins PARP and PARG, elements of the antioxidant defense system and endothelial NO-synthase with the development of target organs lesions in hypertension.

Design and method:

Study population consists of 212 AH patients (pts). The lack of consent to participate, prior myocardial infarction and valvular heart disease were exclusion criteria. There were 94 (44.3 %) men and 118 (55.7 %) women. The mean age of the pts was 60.23 ± 0.74 years, duration of hypertension was 14,2 ± 0,79 years. We found LVH in 127 of 212 pts. LVH pts were older than those without LVH, there were more women than men among them, had a longer arterial hypertension case history and had higher values of maximum systolic blood pressure.

Results:

Association of alleles and genotypes frequencies of PPARG2, PPARG3, PPARA, PPARGC1A, PARP1, ADPRT1 genes and LVH were not found LVH was associated with a higher frequency of 4a allele of NOS3 gene (OR 1,68 CI [1,07–2.62], p = 0,016) and lower frequency of 4b/4b genotype (OR 0,43 [0,23–0,79], p = 0,005) and 4b allele (OR0,59 [0,37–0,93], p = 0,016). Also LVH was associated with a higher frequency of GG genotype (OR 3,61 CI [1,21–12,91], p = 0,024) and G allele (OR = 1,64 CI [1,01–2,67], p = 0,03) and a lower frequency of A allele (OR 0,27 CI [0,07–0,98] p = 0,03) of PARG gene. Carriers of rare GG genotype (A (−431) G of PARG) had a significantly greater LVMM and LVMI compared to carriers of the A allele. Carriers of CC genotype (C24313G) of PPARA gene had statistically significant thicker walls of left ventricular, more LVMM and LVMI and no differences in left ventricular function parameters.

Results:

Carriers of 4a allele of NOS3 gene had significantly greater thickness of the wall of left ventricular and significantly higher LVMI.

Conclusions:

Age, systolic blood pressure, polymorphism of NOS3 and PARG genes were independently associated with LVH in multivariate regression analysis.

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