[PP.11.08] THE ASSOCIATION OF METABOLIC SYNDROME AND ITS COMPONENTS WITH CARDIO-ANKLE VASCULAR INDEX. GENDER DIFFERENCES

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Abstract

Objective:

Cardio-Ankle Vascular Index (CAVI) can reflect peripheral arterial stiffness. Metabolic syndrome (MS) and its components may increase arterial stiffness and the risks of cardiovascular diseases. However, the association of MS and its components with arterial stiffness has not been well studied. The aim of this study was to investigate the association between MS/its components and arterial stiffness evaluate by CAVI in Spanish population with intermediate cardiovascular risk

Design and method:

Cross-sectional study. This study analyzed 2384 subjects who were included in the MARK study, aged 35 to 74 years (mean 61.3 ± 7.7), 61.7% male. Measurement: CAVI using the VaSera device. Metabolic syndrome was defined according to the NCEP ATP III definition. Waist circumference, blood pressure (BP), fasting plasma glucose (FPG) and lipid profile were measured.

Results:

CAVI was significantly higher in males (9.04 ± 1.24) than in female (8.77 ± 1.13) (p < 0.001). In multivariate regression analysis, after adjusting for age, weight, height, antihypertensive drugs, lipid-lowering drugs and antidiabetic drugs, the CAVI maintained a positive association with the MS (β = 0.265 and β = 0.247 p < 0.01), in male and in females. In males CAVI was associate with the BP, waist circumference and triglycerides (β = 0.444; b = 0.195 and β = 0.128; p < 0.05), and in females with the BP and FPG (β = 0.247 and β = 0.231; p < 0.05). The HDL-C no maintained association in both genders. In the logistic regression analysis, after adjustment for confounding factors used in the multiple regression, subjects with higher (CAVI > 9) have twice the risk of having MS, OR = 1.708 in males and OR = 1.849 in females (p < 0.01).

Conclusions:

Metabolic syndrome was positively associated with CAVI. The association of the components of the MS with CAVI differs by gender. Monitoring CAVI can be helpful to identify early stage of arterial stiffness in those people with MS.

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