Cardiovascular risk and prognosis in patients with malignant disorders is a main concern, considering increased number of cancer survivors. Arterial stiffness is a predictor of cardiovascular morbidity and mortality. It was the aim of the present study to find links between blood pressure variables, arterial stiffness and complete blood count in patients with malignant disorders and cutoff values for pathological pulse wave velocity and augmentation index.Design and method:
A total of 49 patients with malignant disorders were investigated using a Mobil-O-Graph, assessing blood pressure variables, pulse wave velocity (PWV) and augmentation index (AI). Complete blood count was available for each patient.Results:
Significant correlations were found between augmentation index, pulse wave velocity and blood pressure variables and complete blood count, respectively. The most important correlations were found for AI and PWV with systolic blood pressure (SBP) (r = 0.428 and 0.644, respectively). Analysis of ROC curves showed significant areas under the curve towards pathological AI, for a cutoff value of less than 27.3% for hematocrit, less than 4.19 million/m3 for red blood cell count, exceeding 2.31 for neutrophil/lymphocyte ratio, more than125 mmHg for SBP, more than 77 mmHg for diastolic blood pressure, exceeding 101 mmHg for mean arterial pressure (MAP) and more than 59 mmHg for pulse pressure (PP). Significant areas under the curve towards pathological PWV were found for a cutoff value of more than 4.06 for neutrophil/lymphocyte ratio, more than145 mmHg for SBP, more than 78 mmHg for DBP, exceeding104 mmHg for MAP and more than 61 mmHg for PP.Conclusions:
Blood pressure variables and complete blood count have a potential diagnostic predictive value for pathological arterial stiffness in cancer survivors. Arterial stiffness should be assessed in cancer survivors with high normal blood pressure, anemia, neutrophilia and lymphopenia.