The aim was to perform a comparative analysis of the parameters of the LDF-gramme and to determine the difference in concentration of endothelin-1 in serum between patients with II-III grades of primary arterial hypertension (AH) and with history of ischemic stroke and in patients with II-III grades of AH only.Design and method:
We followed 45 patients, (aged mean 61,8 ± 9,6), with II-III grades of AH and with high risk of cardiovascular complications: 15 patients with history of ischemic stroke (I group) and a sample of 30 patients without one (II group). Both groups had comparable clinical characteristics. All participants of our study were carried out blood sampling to its research on the concentration of endothelin-1 and were examined using laser doppler flowmetry with LAKK-02 analyzer. Total and specific peripheral vascular resistance were studied with the help computer oscillometry. Results of the study were processed with Statistica 8.0 software.Results:
The concentration of endothelin-1 in serum was significantly higher in the II group (1.95 [25%th- 0,3; 75%th–5,39), than in the I one (0,31 [25%th-0.16; 75%th-1.42]) (p < 0,05). The level of investment of low endothelial flaxmotion component in the microcirculation also differ significantly between two groups (2,43 [25%th-1,78; 75%th-4,26] vs 1,81 [25%th-1,33; 75%th-2,13] accordingly, p < 0,05). The study of vascular parameters identified that total and specific peripheral vascular resistance were significantly higher in the I group (1388 [25%th-1273; 75%th-1504] dyne · cm- 5), than in the II one (1270 [25%th-1089; 75%th-1364] dyne · cm- 5) (p < 0,05). Bypass ratio also was significantly higher in the first group (1,6 ± 0,75) vs (1,22 ± 0,29), accordingly, p < 0,05) due to increased myogenic tone in comparison with the group of patients without stroke.Conclusions:
Elevation of vascular resistance and bypass ratio in the first group because of the increased myogenic tone of the vascular wall. The increased concentrations of endothelin-1 in the serum of patients with AH probably related decline level of investment of endothelial flaxmotion component in the microcirculation.