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The aim was to assess the effects of three-month therapy with bisoprolol on blood pressure and the number of angina attacks in hypertensive persons.

Design and method:

The study comprised 6799 patients with stage I arterial hypertension, aged 61.60 ± 11.54 years. All patients were treated with 2.5 mg or 5 mg bisoprolol for three months. Blood pressure (BP) was measured by an oscillometric device at the beginning of the study, and after three months of therapy. The number of angina attacks at the beginning of the study, and after three months of therapy was self-reported. The differences in blood pressure values and number of angina attacks from baseline were tested with Student's t test for paired samples.


Mean systolic blood pressure (SPB) at the beginning of the study was 147.1 mmHg; mean diastolic blood pressure (DBP) was 90.5 mmHg. After three months of therapy, mean SBP was significantly reduced to 128.9 mmHg, and DBP was significantly reduced to 79.0 mmHg. At the end of the three-month treatment, 27.8% of the patients had normal blood pressure, 51.5% had prehypertension, and 20.7% had stage I hypertension. As for the number of angina attacks, the average number was 2.03 per week at the beginning of the study, but was significantly reduced to 0.91 attacks per week after the therapy. All differences from the baseline values were highly statistically significant (p < 0.001).


Three-month therapy with bisoprolol not only reduces blood pressure in hypertensive persons, but decreases the number of angina attacks after three-month treatment.

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