[PP.14.05] CHANGES IN NATRIURETIC PEPTIDES LEVELS IN PATIENTS WITH HYPERTENSION AND PERSISTENT ATRIAL FIBRILLATION

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Abstract

Objective:

To evaluate the changes in atrial natriuretic peptide (NT-proANP) and brain natriuretic peptide (NT-proBNP) levels in patients with hypertension and persistent atrial fibrillation (AF) treated with propafenone.

Design and method:

The study included 60 patients with hypertension and persistent AF aged 46 to 67 years (mean age 61.1 ± 8.8 years). After the sinus rhythm restoration, patients were divided into 2 groups: the first group (30 patients) was treated with propafenone 450 mg for sinus rhythm maintenance during the next 6 months; the second group (30 patients) received bisoprolol for rate control. All patients were comparable in relation to age, sex, duration of hypertension and AF paroxysms. Natriuretic peptides levels were measured within the first 24 hours after sinus rhythm restoration and after 6 months of treatment.

Results:

On the first day after sinus rhythm restoration elevation of NT-proBNP and NT-proANP was found, there was no significant difference between the groups. NT-proBNP levels in the first and second groups were 160.5 ± 15.2 pg/ml and 158.2 ± 8.6 pg/ml, respectively; NT-proANP levels in the first and second groups were 15.3 ± 6.4 nmol /l and 16.7 ± 8.2 nmol /l, respectively. After 6 months of sinus rhythm maintenance plasma concentration of NT-proBNP and NT-proANP reduced significantly from 160.5 ± 15.2 pg/ml to 130.1 ± 12.2 pg/ml and from 15.3 ± 6.4 nmol/l to 11.5 ± 5.3 nmol/l, respectively, in the first group (p < 0.05). There was no significant difference in NT-proBNP and NT-proANP levels after 6-month treatment period with bisoprolol.

Conclusions:

NT-proANP and NT-proBNP levels in patients with hypertension and persistent AF were significantly reduced after 6 months of sinus rhythm maintenance with propafenone.

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