[PP.14.20] CIRCADIAN CARDIAC AUTONOMIC NERVOUS ACTIVITY AND AVERAGE HEART RATE IN UNTREATED PATIENTS WITH SINUS RHYTHM OF CONGESTIVE HEART FAILURE

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Abstract

Objective:

The research of 24-hour heart rate power spectral in patients with congestive heart failure are relatively rare. The aim of this paper is to study the Circadian changes of cardiac autonomic nervous activity and average heart rate in untreated patients with Sinus rhythm of CHF and to guide the treatment in patients with Sinus rhythm of CHF.

Design and method:

24-hour heart rate power spectral analysis and average heart rate(beat/min)calculating by Holter were performed in 59 untreated patients with Sinus rhythm of CHF and 40 health controls.

Results:

In CHF group than control group, LFnu(88.17 ± 4.36 vs 69.76 ± 8.31 in daytime, P < 0.01; 82.83 ± 6.13 vs 53.10 ± 11.06 in nighttime, P < 0.01) and LF/HF(3.76 ± 0.86 vs 2.15 ± 0.96 in daytime, P < 0.05; 2.36 ± 0.65 vs vs 1.23 ± 0.63 in nighttime, P < 0.05) increased apparently but HFnu(28.12 ± 3.91 vs 36.80 ± 8.36 in daytime, P < 0.05; 32.15 ± 5.49 vs 49.10 ± 11.05 in nighttime, P < 0.01) were decreased apparently both daytime and nighttime. Daytime and nighttime average heart rate in CHF group was higher than control group (96.27 ± 19.56 vs 78.82 ± 12.13 in daytime, P < 0.05; 75.20 ± 16.11 vs 54.53 ± 7.92 in nighttime, P < 0.01).

Conclusions:

In patients with Sinus rhythm of CHF, sympathetic activity was increased from daytime to nighttime but parasympathetic activity was decreased. These changes may be correlation to rising of daytime and nighttime average heart rate(especially at nighttime). The main clinical implication of our study is to provide the evidence for beta blocker treatment in patients with Sinus rhythm of CHF.

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