[PP.15.06] BLOOD PRESSURE VARIABILITY IN HYPERTENSIVE PATIENTS AND DIASTOLIC/ SYSTOLIC FUNCTION OF THE LEFT VENTRICLE

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Abstract

Objective:

Our aim was to study any possible correlation between indices of diastolic/ systolic function of the left ventricle to the 24-hour blood pressure (BP) variability among hypertensive patients.

Design and method:

845 hypertensive patients (438 males), treated (N = 222) or newly diagnosed untreated (N = 623), mean age of 52 years, body mass index: 27 kg/m2, mean systolicBP/ diastolicBP: 143/91 mmHg and mean heart rate of 76 beats per minute, underwent 24-hour ambulatory BP recording and transthoracic echocardiographic/Doppler exam. The early-diastolic and end-diastolic velocities of the transmitral valve flow were recorded.

Design and method:

In a subgroup of 105 patients, indices of diastolic and systolic function of the left ventricle were measured using Tissue Doppler Imaging (TDI). The aforementioned parameters were correlated on the 24-hour BP variability and possible correlations between them was examined for values of 24-hour SBP variability >15 mmHg or <15 mmHg.

Conclusions:

In hypertensive patients, treated or newly diagnosed untreated, the 24-hour variability of the SBP significantly correlates principally with indices of left ventricle's diastolic function and its filling pressures, as well as with indices of its systolic function.

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