[PP.16.06] EVALUATION OF DIASTOLIC FUNCTIONS, PULSE WAVE VELOCITY AND MYOCARDIAL PERFORMANCE INDEX IN PATIENTS WITH PRIMARY PREMATURE OVARIAN FAILURE

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Abstract

Objective:

Epidemiological studies suggest that women with loss of ovarian function at early ages may have increased risk of cardiovascular disease. In this study, we aimed to evaluate diastolic functions, pulse wave velocity and myocardial performance index in primary premature ovarian failure patients (POF) without cardiovascular disease.

Design and method:

We enrolled 51 patients (mean age 38,9 ± 6,9 years) with POF and 55 healthy subjects (mean age 38,1 ± 6,8 years). All participants underwent echocardiographic examination and pulse wave velocity measurement.

Results:

Both groups were similar with regard to age, body mass index and left ventricular ejection fraction. When diastolic functions were assessed, patients with POF had higher mean E/E’ratio (9,3 ± 1,9 and 7,4 ± 1,5, p < 0.001). POF patients have impaired myocardial performance index (0.48 ± 2.2 and 0.40 ± 2.2, p < 0.01) and pulse wave velocity (5.6 ± 0.7 and 5.3 ± 0.7 m/s, p = 0.03) than controls.

Conclusions:

Our study results suggest that diastolic functions, myocardial performance index and pulse wave velocity impaired in patients with POF than controls. Further studies are needed to elucidate the clinical implications of diastolic functions, myocardial performance index and pulse wave velocity in patients with POF.

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