[PP.16.12] IMPACT OF OBSTRUCTIVE SLEEP APNEA ON THE SEVERITY OF SEGMENTAL CORONARY ARTERY BURDEN

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Abstract

Objective:

The purpose of this study was to test the hypothesis that the presence and severity of obstructive sleep apnea determines the severity of coronary artery lesions. Obstructive sleep apnea (OSA) has great impact on cardiovascular outcomes in patients with coronary artery disease (CAD), which is a well known and confirmed by numerous studies fact.

Design and method:

This study included 60 patients (mean age 55 ± 15 years) with arterial hypertension and coronary artery disease, confirmed by clinical and angiographic data, not suffering from diabetes mellitus. All patients underwent sleep study during the course of hospitalization. According to the angiographic data, the angiographic coronary artery disease burden was calculated based on the Gensini scale, which takes into consideration the number of affected segments, as well as the degree of stenosis of each segment. Further, the study included only patients with severe OSA (AHI> 30/hour) or without OSA (AHI <5/hour), (n = 25). All patients were divided into 2 groups: with Gensini score equal or more than 10 (n = 8) and less than 10 (n = 17). Both groups were homogeneous by duration of arterial hypertension and blood pressure levels. The majority of patients 14 (56%) had severe OSA (AHI> 30/hour) and 11 (44%) were without OSA (AHI <5/hour).

Results:

The number of patients, suffering from arterial hypertension as well as coronary artery disease (CAD) and having a high Gensini score appears to be almost equal both for the ones with OSA and those without OSA. Statistical analysis showed no correlation between the severity of OSA and the severity of coronary lesions (y = 1.3711 + 0.0121*x; r = 0.0729; p = 0.5743; r2 = 0.0062). The smaller groups with high and low Gensini score both showed almost equal presence of severe OSA and absence of OSA (p = 1 and p = 0.7416 respectively). Also has been shown no correlation between presence of arterial hypertension and Gensini score (p = 0.7644).

Conclusions:

In our study presence and severity of obstructive sleep apnea has no significant impact on the segmental coronary artery lesions and does not predict the severity of coronary atheromatous burden.

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