[PP.16.20] PROTHROMBOTIC EFFECT OF SERUM URIC ACID IN HYPERTENSIVE PATIENTS

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Abstract

Objective:

The purpose of this study was to investigate the possible relationship of serum uric acid levels (SUA), in hypertensive patients treated or not, with blood clotting factors.

Design and method:

We studied 1038 hypertensive patients (45.9% men) treated or newly diagnosed untreated (mean age 57.6 y, mean systolic/diastolic blood pressure: 148.4/91.8 mmHg, mean heart rate 75 beats per minute, mean body mass index (BMI): 28.2 kg/m2). In the aforementioned patients blood clotting factors were measured, such as fibrinogen, antithrombin III (ATIII), plasminogen activator inhibitor-1 (PAI-1), serum homocysteine (Hcys), and SUA levels. Values obtained, were interrelated with Pearson correlation.

Conclusions:

Serum uric acid levels correlate significantly with blood clotting factors in hypertensive patients, possibly suggesting a prothrombotic effect of SUA in those patients.

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